
Guesthouse vacation rentals in Upstate South Carolina
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouses in Upstate South Carolina
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Upstate South Carolina guesthouses
Family-friendly guesthouses

The Lodge at Pythian Park

The Nest; private tiny home @Reblooming Rose

Holly Hideaway! 10 Highway miles to Clemson U!

Camper at Hickory Lodge and Guesthouse

Private Lakefront Cabin on Lake Greenwood

Private-Lake getaway-7 mile view from dock

Lit'l Bit O' Heaven- Rocky Top Lodge

Blessed Haven - king bed guest house
Guesthouses with a patio

Firefly Cove Guesthouse

Modern Studio near downtown

Yes please we need you! Spacious w/ amazing view!

Spectacular Great Smokey Mountains Views

Starswept Studio–Walk to Brewery, Near BRP & GSMNP

1 bedroom guest house on horse property in Tryon

Cozy guest cottage at The Black Walnut Chateau

May Acres Coop - adorable cottage amidst 15 acres
Guesthouse rentals with a washer and dryer

The Getaway

⭐️⭐️⭐️⭐️⭐️Casita Blanca 🚶🏽➡️Dining, BREWS,SHOPS📍DTWN📍LUX

Just off Main near Taylors Mill - Clean & Comfy

The Guest House By The River

White Squirrel Bungalow

Private North Asheville Bungalow No Cleaning fees

Tryon Foothills Getaway - NC wineries! - TIEC

Hickory Hill Guesthouse
Destinations to explore
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- Rentals with beach access Upstate South Carolina
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- Guesthouse rentals United States
- Blue Ridge Parkway
- Gorges State Park
- Table Rock State Park
- The North Carolina Arboretum
- Chimney Rock State Park
- Tryon International Equestrian Center
- Lake Lure Beach and Water Park
- Ski Sapphire Valley
- Wade Hampton Golf Club
- Jump Off Rock
- Victoria Valley Vineyards
- Discovery Island
- Carl Sandburg Home National Historic Site
- Haas Family Golf
- Saint Paul Mountain Vineyards
- City Scape Winery
- Burntshirt Vineyards
- Overmountain Vineyards
- Wellborn Winery
- Russian Chapel Hills Winery