
Guesthouse vacation rentals in James Island
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouses in James Island
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for James Island guesthouses
Family-friendly guesthouses

CHS Guest house w/ Pool on Golf Course

Bungalow Under The Oaks

Private Coastal Cottage-Near Beaches & Charleston!

Charming Charleston StudioOne!

#1 SC AIRBNB IN MT. PLEASANT OLD VILLAGE. BEACHES!

Liz Lane Cottage- entire guesthouse

Old Mt. Pleasant/Shem Creek close to Sullivans/DT

Ocean Inspired Village Hideaway Old MP
Guesthouses with a patio

Quaint Cottage Studio in Ashley Forest (Avondale).

*Old Village/Shem Creek Charmer*NEW 2BR Guesthouse

Studio 77 in dt Charleston with bikes

Spacious 1 bedroom cottage in Avondale

Driftwood Cottage

The Violet Villa w/no cleaning fee

Cozy Cottage! 5 mins from Kiawah!

5 Star Private Guest House • Heart of Park Circle
Guesthouse rentals with a washer and dryer

Peaceful Garden Cottage Retreat

Beach, downtown, Alhambra Hall weddings so close!

Cozy Cottage w Games, Firepit, Grill, and More!

Amenities! Beach/DT 10m 5bed 3br

Old Village Guesthouse walkable, close to beach/DT

Spacious Daniel Island Apartment

Shem Creek Bungalow: Coastal Comfort Redefined

Guesthouse Convenient to Charleston, Shem Creek, and Beaches
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- Fitness-friendly rentals James Island
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- Park Circle
- White Point Garden
- Hunting Island Beach
- Bull Point Beach
- Secession Golf Club
- Hunting Island State Park Beach
- Children's Museum of the Lowcountry
- Hampton Park
- Sullivan's Island Beach
- Seabrook Beach
- Middleton Place
- The Golf Club at Wescott Plantation
- Front Beach IOP
- Gibbes Museum of Art
- Splash Island Waterpark
- Bulls Island
- The Charleston Museum
- Charleston Aqua Park
- James Island County Park
- Morris Island Lighthouse
- Waterfront Park
- Isle of Palms Beach
- Sandy Point Beach
- Shem Creek Park
- Things to do James Island
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