Guesthouse vacation rentals in Johns Island

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Top-rated guesthouses in Johns Island

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Guest favourite

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 222 reviews

Cozy Apartment in Mount Pleasant

Our place is a cozy and bright garage apartment. It has one bedroom, living room with sleeper sofa, a full bath with tub and fully equipped kitchen. We hope this provides that home away from home feel in a relaxed, yet inviting setting. It is close to dining, the beach and a ten minute ride across the bridge to Charleston. You’ll love our place because of the coziness and the location. Our place is good for couples, solo adventurers, and business travelers. STRPermit# ST240232 SCBUSLIC#20122393

Jan. 19 – 26

$210 CAD per night

Guest favourite

Guesthouse in Charleston

4.93 out of 5 average rating, 708 reviews

Charleston's Coolest Neighborhood

You can't beat the location! You'll be 5-10 minutes from downtown Charleston, but with free off-street parking, AND you can walk to dozens of bars, restaurants, coffee shops, etc. Avondale is Central to all parts of Charleston, and its a cinch to drive to everywhere from here. This studio apartment is private, modern, and newly renovated. You'll have a kitchenette, grill, outdoor seating, and access to beach equipment. Also only a 5 minute walk to the West Ashley Greenway for biking/jogging!

Aug. 22 – 29

$245 CAD per night

Guest favourite

Guesthouse in Charleston

4.91 out of 5 average rating, 170 reviews

Riverland Terrace Guesthouse

Private and quiet guest suite perfect for nature lovers. Our guest house is tucked up against a small marshy area in our backyard on James Island. Located about 5 minutes to downtown Charleston, 5 minutes to John's Island and 15 minutes to Folly Beach. Five minute walk to the Pour House and all terrace area restaurants and the terrace theater. We are a very laid back couple looking for laid back guests who need a quiet and peaceful place to use as their base while exploring Charleston.

Guest favourite

Guesthouse in Charleston

4.93 out of 5 average rating, 170 reviews

Quaint Cottage Studio in Ashley Forest (Avondale)

Take in the peace, calm, and hospitality of Charleston at this small, quaint, stand-alone cottage. The studio is situated on our property and shares an outdoor lounge and dining area. Located in the neighborhood of Ashley Forest, a small corner of Avondale, you are walking distance to breweries, cafes, wine bars, sushi restaurants and more. Downtown is a 10 minute ride share away, and there is also a bus stop five minutes from the property that will take you to the heart of King Street.

Jan. 23 – 30

$207 CAD per night

Guest favourite

Guesthouse in Charleston

4.91 out of 5 average rating, 125 reviews

Centerville Loft, Studio Apt on James Island

Welcome to the Centerville loft. They don't call it Centerville for nothing! This space is in a quiet neighborhood at the center of James Island 4–5 miles from Downtown Charleston and 6 miles from Folly beach. This property is a back yard studio apt with a small kitchenette with microwave, mini fridge, Keurig coffeemaker, magic bullet smoothie blender, 32” TV, record player with records, bluetooth, and a patio. We are within walking distance to several restaurants along Folly road.

Aug. 13 – 20

$221 CAD per night

Guest favourite

Guesthouse in Charleston

4.97 out of 5 average rating, 243 reviews

Urban Oasis, West of the Ashley

Private, renovated guesthouse in a quiet neighborhood. Studio includes everything needed for a short or long stay, including a kitchen with a stove and microwave for cooking, seating area to relax, and beautiful deck to enjoy the outdoors. Separate entryway and fenced in area for ultimate privacy. Convenient to all the charm Charleston offers, including: 5 miles to downtown, biking distance to great restaurants and bars, 12 miles to Folly Beach and 14 miles to Sullivan's Island.

Mar. 4 – 11

$263 CAD per night

Guest favourite

Guesthouse in Mount Pleasant

4.98 out of 5 average rating, 214 reviews

Bungalow Under The Oaks

Small guest house in the heart of Mount Pleasant! Ideally located to both Isle of Palms and Sullivan's Island beaches (both 7 minutes) and only 15 minutes to the heart of historic downtown Charleston. Our private guest bungalow is a perfect launching spot for all your exploring. End the day relaxing under the shade of our mature live oak. The house has its own entrance and separate yard that is fully fenced in. LHR Permit: ZSTR-02-21-00318, License: LIC-3-21-252314.

Sep. 21 – 28

$260 CAD per night

Guest favourite

Guesthouse in Charleston

5.0 out of 5 average rating, 216 reviews

James Island "La Casita" Nestled btw Beach & City

Wake up to the 2 grand oaks just outside your window. Visit Folly Beach (14 minutes) or Historic Downtown Charleston (9 minutes). Craft your own meal in the complete kitchen or try one of the many renowned Charleston restaurants recognized by foodies worldwide. Visit James Island County Park & Waterpark (1 mile). Take a trip to the local Farmer's Market or the Municipal Golf Club. Then stroll down the (Woodland Shores) road for a spectacular view of the wetlands.

Aug. 13 – 20

$267 CAD per night

Guest favourite

Guesthouse in Mount Pleasant

4.97 out of 5 average rating, 405 reviews

Guesthouse Convenient to Charleston, Shem Creek, and Beaches

Relax in this separate guest home nestled in a well-established Lowcountry neighborhood. The ‘treehouse’ has an open-plan design with vaulted notched board ceilings, creating a feeling of light and space, with elegant furnishings throughout. The well-equipped kitchen and grill on the porch encourages intimate home cooking. We lived in this space before we moved into the main house, so we can attest to it being comfortable, and well maintained.

Dec. 11 – 18

$269 CAD per night

Guest favourite

Guesthouse in Johns Island

5.0 out of 5 average rating, 103 reviews

Cozy Getaway Nestled in Nature

Welcome to your ideal retreat, perfectly situated only 20 minutes from Folly Beach, 15 minutes from Kiawah, and a short 15-minute drive to the vibrant heart of downtown Charleston. Recent guests have great things to say! "Extremely clean and cozy cottage...10/10 would recommend! " - Anastasia "This place is a true hidden gem, it looks exactly like it’s pictures." -Hailey "This AirBnB was probably the best I've experienced so far. " -Susan

Apr. 11 – 18

$301 CAD per night

Guest favourite

Guesthouse in Charleston

4.97 out of 5 average rating, 220 reviews

Lady Ashley Studio Apartment minutes to downtown

Welcome to our spacious studio loft. The private detached unit is located in the heart of James Island in a friendly neighborhood. We are within walking distance to a row of restaurants/bars, a ropes course, fitness gym, a grocery store , and only a short six miles (5-15 mins drive) to Folly Beach and Downtown Charleston. We have a sweet pup who likes to greet you in the backyard and a sweet cat who roams around all the time.

Jul. 20 – 27

$228 CAD per night

Guest favourite

Guesthouse in Johns Island

4.96 out of 5 average rating, 212 reviews

River Rd Retreat with Salt Wtr Pool, min to Beach

Gorgeous guest retreat above detached garage with pool access. Seven miles from Historic Downtown Charleston. Minutes from restaurants and the beach. This cottage is the best place to celebrate a special occasion! Send simple decorations through Amazon and we will decorate for you! Beach chairs, umbrella, and towels provided for your day at the beach. Kayaks and bikes available.

Mar. 8 – 15

$293 CAD per night