House vacation rentals in Panama City

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Top-rated house rentals in Panama City

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Guest favourite

Home in Panamá

4.95 out of 5 average rating, 37 reviews

Cantabria House - 10 minutes from the Airport

Spacious and comfortable home just 10 minutes from Tocumen Airport and only 200 meters from the Metro. Perfect for families, groups, or business trips. Fast 500 Mbps Wi-Fi, 3 bedrooms, 2 full bathrooms, fully equipped kitchen, air conditioning throughout the house, cable TV, patio with outdoor furniture, private parking, and self check-in. Long layover, family trip, or work in the city? This home has it all: comfort, location, and privacy. Book now and feel at home from the very first moment!

Top guest favourite

Home in Panama City

5 out of 5 average rating, 47 reviews

Mountain Retreat

Relax and unwind at this peaceful property nestled on two hectares of lush tropical vegetation surrounded by the sights & sounds of nature. Located at Panama's Blue Mountain(Cerro Azul), 30 kilometres from Panama City. This cozy & comfortable home is equipped with modern amenities & chic decorative touches. It consists of a main house with 2 bedrooms & a 2 bedroom cottage. It has a spacious terrace, pool & jacuzzi overlooking Panama City. The property also boasts its own spring water well

Superhost

Home in Veracruz

4.9 out of 5 average rating, 10 reviews

¡Villa de Lujo frente a la playa!

Descubre el lujo en nuestra Nueva villa frente al mar en Veracruz Chumical, a solo 30 min de la Ciudad de Panamá. Con 5 habitaciones, 6 baños, 4 camas king y 2 camarotes dobles, es ideal para familias y amigos. Relájate en la piscina infinita con vistas espectaculares o disfruta de la cocina equipada, la sala espaciosa y la zona de barbacoa. Contempla los buques iluminados en la azotea y vive una experiencia única. ¡Reserva ahora y disfruta siendo el primero en nuestra hermosa Villa!

Guest favourite

Home in Panamá

4.87 out of 5 average rating, 38 reviews

Naturaleza maravillosa

Disfruta de un retiro familiar en plena naturaleza, donde la tranquilidad te envuelve. Este acogedor alojamiento, rodeado de un hermoso jardín en el Parque Natural Metropolitano, te ofrece un escape único a solo 3 minutos del Albrook Mall y 5 minutos del centro. Despierta con el canto de las aves y la visita de ñeques, mientras te relajas en un ambiente exclusivo y lleno de vida. ¡La escapada perfecta para desconectar y disfrutar de la naturaleza con todas las comodidades!

Guest favourite

Home in Panamá

4.87 out of 5 average rating, 15 reviews

Charming House in Casco Viejo

This recently renovated house is an absolute treasure. It blends history, charm, and modern comfort. Archeologists uncovered artifacts dating to the seventeenth century. Tastefully furnished with modern comforts and antiques, it's steps away from the Panama Canal Museum and in the heart of Casco Viejo, perfect for guests looking to immerse themselves in the cultural and culinary delights before retreating to the comfort and tranquility of their temporary home.

Guest favourite

Home in Panamá

4.92 out of 5 average rating, 60 reviews

Unique 4 room house - direct access to the beach

Welcome to Casa Playa, your haven in the heart of Casco Viejo! This elegant property blends the historic charm of the area with modern comfort and style. It features 4 cozy bedrooms, each with its own private bathroom, a fully equipped kitchen, living and dining areas, and an in-unit laundry center. Perfect for groups of up to 8 guests to share in an exclusive and comfortable setting. Enjoy an unforgettable stay in a warm, spacious, and fully equipped space.

Superhost

Home in Panamá

4.83 out of 5 average rating, 40 reviews

Swette Love 10 min. del aeropuerto.

Bienvenidos a nuestro acogedor apartamento ideal para dos a tres personas! con un baño y una cocina equipada. Aunque solo tiene una ventana frontal, el apartamento está perfectamente climatizado con aire acondicionado y cuenta con ventiladores en ambos dormitorios. Disfrutarás de la tranquilidad y seguridad que ofrece nuestro vecindario, permitiéndote relajarte y descansar plenamente durante tu estadía. ¡Te esperamos para una experiencia inolvidable!

Guest favourite

Home in Panamá

4.93 out of 5 average rating, 370 reviews

Estudio Privado a 10 Min del Aeropuerto !

Apartamento Entero a 10 MINUTOS del Aeropuerto! El apartamento está completamente amueblado incluyendo electrodomésticos y artículos de cocina , productos de aseo , sala comedor ,mesa de trabajo y demás. A sólo minutos caminando de la Estacion de METRO SAN ANTONIO, restaurantes, centros comerciales,lavanderias,supermercados y farmacias. Ofrecemos Tours a San Blas para que aproveches al maximo tu viaje. Nuestra casa es Tu casa en Panamá 🇵🇦

Top guest favourite

Home in Panama City

4.8 out of 5 average rating, 107 reviews

Spacious Panama House in the 'heart of the city'

You couldn't ask for a better place to stay while you visit Panama. This location is perfect, while other properties might advertise similar amenities; not one of them can boast a combination of space and amazing location quite like this one. This is very private & secure property in a fantastic, & very safe area right in the heart of the city & close to everything! An oasis in the middle of the city with AC IN EVERY ROOM AND DININING ROOM.

Superhost

Home in Panamá

4.92 out of 5 average rating, 13 reviews

Modern 3bed home near city conveniently located

This special place is close to everything, making it easy to plan your visit. It is perfect for group of persons or family trips. Conveniently located just in front of the house you will find a mini market! You will be minutes from train station, shopping malls and 20 min away from the city. Don bosco is a safe place. You’ll find all you need in this home at a very affordable price. You will love this place!

Guest favourite

Home in Panamá

4.93 out of 5 average rating, 124 reviews

Exceptional three-story building with sea view

This stunning three-story property, located in Casco Viejo, boasts a terrace with a sea view. Designed with a focus on elegance and relaxation, the house features spacious and well-lit interiors adorned with modern and high-quality decor. The strategic location of the house allows for breathtaking views from the terrace, offering a unique blend of luxury and relaxation in a historic and picturesque setting.

Guest favourite

Home in Panamá

4.92 out of 5 average rating, 155 reviews

Golden Space | By Paradox

PRIVATE APARTMENT IN PANAMA CITY, CLOSE TO CASCO VIEJO. If you're looking to get submerged into real Panama and live among the real locals. This is the right place to be. For More Info or visual content, follow us on IG as Paradox Experience and visit our Virtual Showcase with the link in our IG BIO. More than a regular stay, we are an experience.