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Boutique hotel vacation rentals in Panama
Find and book unique boutique hotels on Airbnb
Top-rated boutique hotels in Panama
Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Panama boutique hotels
Family-friendly boutique hotels
![](https://a0.muscache.com/im/pictures/c126650f-b4ac-44ad-889c-c6a9c8696606.jpg?im_w=720)
Hotel room in Boquete
4.73 out of 5 average rating, 59 reviewsCabañas Villa San Miguel #5 / Boquete.
![](https://a0.muscache.com/im/pictures/d26fbcdd-acf2-46cc-8929-b90346518f95.jpg?im_w=720)
Hotel room in Punta Chame
5 out of 5 average rating, 8 reviewsPink Palace Panama
![](https://a0.muscache.com/im/pictures/109306392/c178d670_original.jpg?im_w=720)
Hotel room in Copecito
4.74 out of 5 average rating, 31 reviewsB&B Cabanas los hummingbirds
![](https://a0.muscache.com/im/pictures/8b10dcaf-8db4-4b7e-9f45-9874a9d13b0f.jpg?im_w=720)
Hotel room in Puerto Armuelles
4.53 out of 5 average rating, 19 reviewsBeachfront Ocean Suite with Swiming Pool
![](https://a0.muscache.com/im/pictures/71effd27-8f2d-4547-a2a9-9af64774aba9.jpg?im_w=720)
Hotel room in isla contadora.
4.75 out of 5 average rating, 8 reviewsBeautiful B&B with unbeatable customer care!!!
![](https://a0.muscache.com/im/pictures/be958dee-f6e3-41b5-a8b0-d9363b211abf.jpg?im_w=720)
Hotel room in Portobelo
Beachfront Boutique Hotel and Restaurant Portobelo
![](https://a0.muscache.com/im/pictures/miso/Hosting-21700420/original/eeea4664-2e0c-4964-8dfa-c34f84cf30cb.jpeg?im_w=720)
Hotel room in Playa Venao
4.6 out of 5 average rating, 10 reviewsPlaya Room - First floor family space, ocean views
![](https://a0.muscache.com/im/pictures/miso/Hosting-19403376/original/0e83e2ef-d926-4007-b664-43164479596b.jpeg?im_w=720)
Hotel room in Soná
5 out of 5 average rating, 5 reviewsVilla Coco Twin Room
Boutique hotels with a patio
![](https://a0.muscache.com/im/pictures/miso/Hosting-54167637/original/c1a4a083-ecb7-4de3-9332-a1fcd7c15eae.jpeg?im_w=720)
Hotel room in Bocas del Toro
4.72 out of 5 average rating, 18 reviewsOver the Sea Turtle Mini Cabin with Veranda
![](https://a0.muscache.com/im/pictures/miso/Hosting-736281238397440404/original/575bb340-8a9d-478c-8531-c8ddc99db3c1.jpeg?im_w=720)
Hotel room in Pedasi
4.75 out of 5 average rating, 16 reviewsRoom in Hostel Boutique; Private Bathroom
![](https://a0.muscache.com/im/pictures/miso/Hosting-711487192250630110/original/b195910d-738d-4d7b-9b5b-89ce7a81b54f.jpeg?im_w=720)
Hotel room in Lagartero
4.75 out of 5 average rating, 12 reviewsCharming 1-Bedroom Beachfront Hotel With Pool
![](https://a0.muscache.com/im/pictures/hosting/Hosting-U3RheVN1cHBseUxpc3Rpbmc6OTAyMDA3MTM4ODgzNTU1ODk4/original/0ffe7753-491a-4d4c-a8ca-a8e83dca9db6.jpeg?im_w=720)
Hotel room in Panamá
5 out of 5 average rating, 3 reviewsEshel Panama Suites, Atlantic suite 04
![](https://a0.muscache.com/im/pictures/e9623433-1184-4fdd-94f5-cf4ae2cd1d11.jpg?im_w=720)
Hotel room in El Valle de Antón
4.5 out of 5 average rating, 10 reviewsSuite medievale natura & arte
![](https://a0.muscache.com/im/pictures/miso/Hosting-932547878910761912/original/eea768f0-ac4d-48d1-817c-fe1e1bea0436.jpeg?im_w=720)
Hotel room in San Carlos
5 out of 5 average rating, 3 reviewsLa Maracuyá Panama_ splendid large Room in Nature
![](https://a0.muscache.com/im/pictures/miso/Hosting-546551781155511201/original/5c6c2560-d98c-4999-8b75-297a7f63d346.jpeg?im_w=720)
Hotel room in Soná District
4.5 out of 5 average rating, 6 reviewsGarden View Double Bedroom at Nativo
![](https://a0.muscache.com/im/pictures/miso/Hosting-732847916352699823/original/878c1c08-4f29-4538-a4db-d9dd5d2e2fb9.jpeg?im_w=720)
Hotel room in Panamá
Charming Hotel in Casco Viejo Corner Suite
Monthly boutique hotel rentals
Destinations to explore
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