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Mansion vacation rentals in Panama

Find and book unique mansions on Airbnb

Top-rated mansion rentals in Panama

Guests agree: these mansions are highly rated for location, cleanliness, and more.

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Home in Bastimentos

4.81 out of 5 average rating, 107 reviews

Spacious, Over the Water Home with Plunge Pool

Perched over the water in Bastimentos Bay, this well-appointed four bedroom and three bath single family home combines classic Caribbean architecture with modern sensabilities. With over 2,000 sq ft of comfortably furnished spaces, there’s room enough for eight adults to spend time together - or apart - in any weather. BBQ poolside, stargaze from the hammocks, fish off the dock, walk to restaurants, or flag down a water taxi from your private boat dock for the ten minute trip to Bocastown.

Guest favourite

Condo in Buenaventura, El Chirú

4.99 out of 5 average rating, 114 reviews

Stylish & Quiet ~ Breathtaking Laguna Views ~Pool

➡️ The highest rated w more than 60 reviews! ⬅️ Welcome to "The Gliding Damselfly," the MOST stylish 4BR 4Bath flat nestled in the majestic Buenaventura, perfect for escaping city crowds and enjoying mesmerizing views, stunning beaches (5 mins), and lavish pools (2 mins). Explore the area and its exciting attractions, and then retreat to the breathtaking sanctuary that will leave you in awe. ✔ 4 Comfy BRs ✔ Open Design Living ✔ Full Kitchen ✔ Terrace ✔ Smart TVs ✔ Fast Wi-Fi See more below!

Guest favourite

Earth homes in El Cope, Penonome

4.92 out of 5 average rating, 153 reviews

Beautiful Eco House in Panama

We are very pleased to offer our beautiful, modern, comfortable house designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and escape daily stress. It is in a beautiful part of Panama near a cloud forest national park. The house sits in 17 acres of forest and has 2 rivers for swimming. The house is very open allowing full enjoyment of nature. There are amazing hiking opportunities in the mountains with waterfalls and visits to local communities.

Guest favourite

Home in San Carlos

4.94 out of 5 average rating, 100 reviews

OceanView-Rooftop Jacuzzi&Pool | Concierge Service

Unique 3-story beach house – one of a kind. 7 bedrooms, 13 beds, 7.5 baths. hot water. Every room with full bath -AC’s and ceiling fans in all rooms, separate laundry -Rooftop area pool, Jacuzzi, bar, BBQ(charcoal & gas) with amazing ocean view -High ceilings, large open kitchen and living area. -Spacious balcony for dining or relaxing. - 5 min. walk to the beach. -Parking for up to 7 cars - Base price covers 4 guests (additional charge $40 per person). Sleeps up to 25 guests.

Guest favourite

Villa in Punta Chame

4.99 out of 5 average rating, 110 reviews

Beach House with Pool/Gazebo in Punta Chame!

"Disconnect from the routine and enjoy a sunny environment. Just breathe fresh air in a different surroundings. Enjoy a few days in the pool, relaxed in a hammock and of course steps from a spectacular beach with views of the city and islands. The house has 4 bedrooms, 3.5 bathrooms, electric plant and all the facilities to enjoy and rest. Close to restaurants and the best beach to do and see kitesurfing adventures, fish, SUP, etc. Only 90 minutes from the city"

Home in Vista Mar Golf, Beach & Marina

4.88 out of 5 average rating, 236 reviews

Luxurious Beach House - Private Pool Golf & Marina

Vista Mar Golf, Beach & Marina is a gated community with private security, with direct access to a state of the art golf course designed by J. Michael Poellot. It also has marina, heliport, tennis courts, direct private beach access, bars and restaurants. The house comes with an outdoor private pool & hot tub, also a amazing private outdoor kitchen, and an amazing sea view with spectacular sunrises and sunsets. any inquiry please contact 66168596

Guest favourite

Home in Las Colinas de Caceres de Arraijan

4.98 out of 5 average rating, 199 reviews

Tropical Haven with Yoga Platform

Tropical "open-concept" Airbnb, with a private pool and yoga/meditation platform, located in a typical village, 20 minutes outside the hustle of Panama City, Panama - Central America. This modern contemporary tropical home is located in the hills of Caceres on a 5 acre finca full of tropical trees, birds, and a manicured grounds. Outdoor gas and charcoal barbecue off of back patio with vertical herb garden for perfect relaxation retreat.

Guest favourite

Home in Río Hato

4.98 out of 5 average rating, 112 reviews

Spacious Vacation Home in a Tourist Area

Cozy & comfy villa with great illumination and natural ventilation located in the Playa Blanca Beach & Lagoon complex in Rio Hato, Cocle just 10 minutes away from Scarlett Martinez International Airport and 90 minutes from Panama City. Playa Blanca is an exclusive tourist residential beach complex with villas, apartments, big lush green areas, the largest pool in Central America, beach club, Playa Blanca Hotel Resort and much more.

Guest favourite

Home in El Valle de Antón

4.94 out of 5 average rating, 136 reviews

Rustic family mountain home - 5 min walk to town!

Rustic family home with exquisitely landscaped garden complete with bridge over natural stream. Outdoor chill out space with barbecue and terrace under roof with hammocks on one side of the house, and a pergola with lounge area and gas grill on opposite side of the house. Centrally located to main attractions, only a 7 minute walk to the main market. Peaceful, relaxing refuge surrounded by views of nature and the cloud forest.

Guest favourite

Cottage in Altos del Maria

4.92 out of 5 average rating, 119 reviews

Mountain Cottage with Great View and Heated Pool

Casa de Montaña, with spectacular views of the mountains of Altos del María, perfect to rest or spend it with family, with heated pool, spacious outdoor spaces, Smart TV and A/A in all rooms, WIFI throughout the property and fully equipped. Includes Prime Video service. It has fire pit and a gas fired BBQ. For weekend rentals coming out Domingo, you give late check-out complimentary.

Guest favourite

Villa in Farallon

4.9 out of 5 average rating, 209 reviews

4 Bedroom Costa Blanca Golf & Beach Villa

Spacious 4 bedroom, 4.5 bathroom, 250m detached villa overlooking the 7th putting green on Mantaraya Golf Course. Accommodation provided for up to 12 people within 4 bedrooms. The 15m long swimming pool plus shallow area in rear garden is totally private. Villa guests have access to the Property Owners Beach Club and Restaurant.

Guest favourite

Condo in Buenaventura, El Chirú

4.91 out of 5 average rating, 108 reviews

Modern | Steps to Beach Club & Shops | Sleeps 10

★ A Proper Rents Experience ★ • Beautiful design • Excellent location • Steps to the La Mansa Beach Club! • Spacious & luxurious • Luxury Bedding • 75 inches TV • Beautiful views! • Half a block from restaurants & convenience store! • Fully equipped • High speed internet • Buenaventura, best luxury beach resort in Panama

Vacation rentals for every style

Get the amount of space that is right for you.

Cottages

Quaint homes, peaceful surroundings

Cabins

Kick off your hiking boots at these rustic lodgings

Bungalows

Intimate homes, inviting architecture

Popular amenities for Panama mansion rentals

Free parking on premises

Air conditioning

Luxury mansion rentals

Guest favourite

Villa in Las Lajas

4.86 out of 5 average rating, 21 reviews

Donde Emy Beach House

Villa in Playa Venao

4.8 out of 5 average rating, 45 reviews

Villa Nomada -Barefoot Luxury Beach Front Villa

Guest favourite

Condo in Maria Chiquita

5 out of 5 average rating, 43 reviews

Playa Escondida Lux Beachfront Haven:Oceanview Apt

Boat in Río Azúcar

5 out of 5 average rating, 3 reviews

Private Luxury Catamaran

Home in Coronado

4.71 out of 5 average rating, 21 reviews

CHARMING ALMAR FRONT HOUSE WITH PISCINA-CORONADO

Villa in San Carlos

4.77 out of 5 average rating, 35 reviews

Villa Serenidad by AcoModo

Guest favourite

Rental unit in Maria Chiquita

4.96 out of 5 average rating, 23 reviews

Penthouse in Playa Escondida 4 bedrooms

Guest favourite

Villa in Panamá

4.98 out of 5 average rating, 45 reviews

Breathtaking Views Mansion w/King Beds

Pet-friendly mansion rentals

Guest favourite

Vacation home in San Carlos

4.89 out of 5 average rating, 37 reviews

Welcome to our house in Playa Corona

Guest favourite

Condo in El Chirú

4.87 out of 5 average rating, 93 reviews

Buenaventura beach condo with private pool

Home in PA

4.8 out of 5 average rating, 90 reviews

Villa GiGi - Beach Home Panama Santa Clara

Guest favourite

Rental unit in Buenaventura

5 out of 5 average rating, 83 reviews

Exclusive apartment steps from the sea in Puntarena

Guest favourite

Home in Nueva Gorgona

4.91 out of 5 average rating, 22 reviews

Casa de las Palmas

Guest favourite

Home in Nueva Gorgona

5 out of 5 average rating, 7 reviews

Spectacular Beachfront House

Guest favourite

Home in Playa Bluff

4.93 out of 5 average rating, 29 reviews

Jungle House 100m from the beach

Guest favourite

Rental unit in El Chirú

4.94 out of 5 average rating, 89 reviews

Buenaventura Golf & Beach Resort Lux Apartment

Mansion rentals with a pool

Guest favourite

Villa in Río Hato

5 out of 5 average rating, 25 reviews

Villa Agueda Decameron, Golf Club & Pool

Guest favourite

Rental unit in Maria Chiquita

5 out of 5 average rating, 19 reviews

Playa Escondida ocean and lagoon #vacfamilia

Guest favourite

Condo in Maria Chiquita

4.9 out of 5 average rating, 30 reviews

PLAYA OCULIDA BELLEO APARTMENT

Guest favourite

Rental unit in Panama City

4.96 out of 5 average rating, 24 reviews

22M Spectacular Penthouse New Design Oceanview

Guest favourite

Rental unit in Maria Chiquita

4.86 out of 5 average rating, 22 reviews

Playa Escondida, luxury ocean view apartment

Guest favourite

Condo in San Carlos District

4.95 out of 5 average rating, 39 reviews

Punta Caelo Beach Front View

Villa in Río Hato

4.92 out of 5 average rating, 76 reviews

(Panama) Beach house with golf course.

Townhouse in Nueva Gorgona

5 out of 5 average rating, 3 reviews

Lux Beachfront Oasis in Gorgona

Destinations to explore