
Guesthouse vacation rentals in Panama
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouses in Panama
Guests agree: these guesthouses are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you.
Popular amenities for Panama guesthouses
Family-friendly guesthouses

A Remote Paradise in nature - Ocean View

(5) The Beach House Inn - The Santa Cruz Room

Toucan Bay Lodging & Holistic Services

Our green house

Casita Verde 411

Cozy attached house in a quiet neighborhood

Efficiency Bungalow - Metropolitan Natural Park

2 bedrooms in tropical garden
Guesthouses with a patio

Volcano View Cottage

• Coronado Guesthouse Zuramaya •

El Valle Casita

Q&B Inn Cozy One-Room Apartment #2

Rustic Private Studio Near Downtown

Casa Colibri, new in 2025! Prvt prop near beach

Modern Casita just a short walk to the beach

Olé #2 | Close the beach, restaurants, activities
Guesthouse rentals with a washer and dryer

Cozy cabin w/ Queen Bed & ensuite 10 mn from Beach

Casa Tropical Boquete, Duplex#1 2R /2BR

Pool House with Shared Pool Access

Studio with Pool Near Beaches in Bocas del Toro

Private cabin and CasaMomote river, Loma Limón.

Bamboo Cabin

Alicia's Cabins 1

Cozy, quiet and great location!
Destinations to explore
- Rentals with an EV charger Panama
- Hostel rentals Panama
- Rentals with an accessible height bed Panama
- Tiny house rentals Panama
- Boutique hotel rentals Panama
- Bungalow rentals Panama
- Nature eco lodge rentals Panama
- Rentals with pools Panama
- Smoking-friendly rentals Panama
- Beach house rentals Panama
- Family-friendly rentals Panama
- Waterfront rentals Panama
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- Hotel rentals Panama
- Lake house rentals Panama
- Apartment rentals Panama
- Beachfront rentals Panama
- Rentals with a kayak Panama
- Townhouse rentals Panama
- Farmstay rentals Panama
- Rentals with a patio Panama
- Rentals with beach access Panama
- Rentals with a washer and dryer Panama
- Pet-friendly rentals Panama
- Condo rentals Panama
- Treehouse rentals Panama
- Cabin rentals Panama
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- Serviced apartment rentals Panama
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- Boat rentals Panama
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- Bed and breakfasts Panama
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- Shipping container rentals Panama
- Villa rentals Panama
- Dome rentals Panama
- Cottage rentals Panama
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- Rentals with a home theater Panama
- House rentals Panama
- Rentals with breakfast Panama
- Fitness-friendly rentals Panama
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- Mansion rentals Panama
- Private suite rentals Panama
- Chalet rentals Panama