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Guesthouse vacation rentals in Panama

Find and book unique guesthouse rentals on Airbnb

Top-rated guesthouses in Panama

Guests agree: these guesthouses are highly rated for location, cleanliness, and more.

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Guest favourite
A charming cottage with a red metal roof is surrounded by lush greenery and colorful flowers. A few small trees and plants frame the image, highlighting the tranquil garden setting and the natural beauty of the hillside location.
Guesthouse in Los Naranjos
4.93 out of 5 average rating, 232 reviews

Sunshine Cottage at Finca Katrina

Sunshine Cottage is a little cottage in the back garden of Finca Katrina. It is set on a hill with views of Palo Alto and Jaramillo with a coffee plantation in the foreground. There is a full (double) bed, room to hang your clothes and to store your belongings. You have a small fridge, toaster oven, sink, coffee maker, and cupboard space for food, but no stove top. If you are looking for more bedrooms, there are additional units on Finca Katrina that compliment Sunshine Cottage. Send us a note!

Top guest favourite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 103 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favourite
A traditional bohio with a thatched roof is set amidst lush greenery. A pathway leads to a serene pool, flanked by vibrant tropical plants and flowers. The surrounding landscape features distant mountains, softly illuminated by the warm light of dusk.
Guesthouse in El Valle de Antón
4.98 out of 5 average rating, 52 reviews

The Retreat in El Valle - Garden House

Welcome to your serene retreat in El Valle, Panama! Nestled amid lush nature, our two-bedroom casitas offer a peaceful escape with breathtaking views, exotic wildlife, and flora. Each casita features a queen bed, choice of king or twin beds in the second room, a small fridge, coffee station, Wi-Fi, and large terrace. Enjoy the shared pool, meditation and healing sessions by appointment, and explore world-class hiking nearby. Just a short walk to restaurants and El Valle’s famous artisan market!

Top guest favourite
A serene view from the guesthouse showcases a private balcony with two chairs and a small table, positioned before lush greenery and distant mountains. The inviting landscape is framed by the sliding glass doors, enhancing the connection to nature.
Guesthouse in Torio
4.91 out of 5 average rating, 140 reviews

Torio guesthouse with panoramic view

Our private guesthouse is suspended over the Torio River, on the west coast of the Azuero Peninsula. It is a paradise for hikers, bird watchers, surfers and beach goers. Marked trails with posted maps begin at our place. Hike to a beautiful waterfall, mountain or beach. Photograph birds from the porch. Surf, body board and swim safely (no strong currents). Walk to good restaurants, and a small grocery. Experienced Surfers have Morrillo Beach and Playa Reina. Watch sun and moon rise.

Guest favourite
A private swimming pool with a waterfall is surrounded by lush greenery, providing a tranquil setting. A thatched-roof structure is visible nearby, creating an inviting space for relaxation. Colorful flowers and plants enhance the outdoor area, making it suitable for leisurely outdoor dining.
Guesthouse in Rio Hato
4.89 out of 5 average rating, 106 reviews

Sustainable Guest house with Pool in Rio Hato

Discover Rancho Ahome, a serene 2BR 1Bath guesthouse in Rio Hato. Escape to tranquility, 5 mins from stunning beaches, and enjoy our private pool with a waterfall. Immerse in nature on our sustainable farm, home to fruits, rabbits and chickens. Perfect for those seeking peace and an eco-friendly retreat, Rancho Ahome offers a blend of comfort and adventure amidst breathtaking landscapes. Experience a peaceful sanctuary that’s close to nature yet filled with comfort. We are pet friendly.

Top guest favourite
The Sky Cabin is surrounded by vibrant tropical foliage and flowering plants, showcasing a colorful exterior. A stone pathway leads to the cabin, with a covered outdoor area visible, ideal for enjoyment in the garden's serene environment.
Guesthouse in La Ermita de San Carlos
4.97 out of 5 average rating, 124 reviews

Rural+comfy: AC, WiFi, hot water, pool, private

The Sky Cabin is part of 5 cabins “A Piece of Paradise” With registration in the Panamanian Tourism Authority Bureau. ✸ Ideal for a couple or a single person ✸ Outdoor dining area and kitchen ✸ Spacious terrace with a hammock ✸ Very quiet neighborhood ✸ Private and public transportation available, just ask and we will help you ✸ 7-10 minutes, by car, from Playa La Ermita and 10 minutes from Playa El Palmar (great spot for surfing) ✸ Breakfast for an additional $7.00, for each guest.

Superhost
A cozy sleeping area features a spacious bed with neutral-toned bedding, complemented by a textured throw. A small workspace with a table and chair is positioned nearby. A wardrobe provides storage, and light enters through a window with simple coverings. Air conditioning unit is mounted on the wall.
Guesthouse in Panamá
4.71 out of 5 average rating, 7 reviews

The Black Studio by SS • near airport & city

This unique PRIVATE place has a style all its own. This stylish place is anything but ordinary. It is affordable and its perfect for a couple or business trips. Conveniently located next to shopping malls and supermarkets you’re literally 3 minutes from the train station and just 20 minutes to the city. Don Bosco is a safe place. Enjoy a cozy place with everything you can need for your stay. This place is private with its private entrance. IT IS NOT SHARED!

Top guest favourite
Guesthouse in Panamá
4.76 out of 5 average rating, 245 reviews

Garden Cottage in Panama City

Welcome to our charming cottage, an oasis in the heart of the city, ideal for nature lovers and comfort seekers. Located in a central area, this retreat offers the perfect combination of tranquility, comfort, and proximity to Panama's main attractions. Enjoy the balance between urban life and the serenity of the natural surroundings. It features a private entrance, a spacious garden, a barbecue area, and a terrace where you can relax and connect with nature.

Guest favourite
A small pool sits within a wooden deck area, surrounded by lush greenery. Steps lead from the deck to the pool, where a gentle waterfall feature adds a soothing element. Lounge chairs are positioned nearby for relaxation in a tranquil setting.
Guesthouse in Panamá Oeste
4.81 out of 5 average rating, 101 reviews

Mountain House in Panama

Enjoy peace and nature in this cozy and equipped cabin, perfect for disconnecting and relaxing. Surrounded by forests and with spectacular views, here you can breathe pure air and gaze at the stars. ✔️ Great for couples, families or adventurers. Nearby ✔️ trails, rivers and viewpoints. ✔️ Comfortable and equipped spaces for your comfort. - Capacity of 4 people - Possibility of having 1 double bed and 2 singles or 4 single beds - Discount from two nights

Guest favourite
A small balcony is visible, featuring a round wooden table set with two white chairs. The view shows calm, clear waters with a vibrant yellow bungalow in the background. Light glistens off the water, creating a serene atmosphere.
Guesthouse in Bocas del Toro
4.92 out of 5 average rating, 63 reviews

The Boat House in Big Bight

Come relax in this peaceful over the water ECO bungalow on Isla Colon, on a coral reef 15 minutes away from town BY BOAT ONLY.. See lots of stars in the sky, tons of sea life & stunning sunsets from your balcony! Enjoy Starfish Beach, just a 5 minute boat ride away. Red Frog Beach, Playa Bluff, Zapatillas, & much more while you're here in Bocas Del Toro! (Kitchen is provided with basic cooking essentials & bathroom with basic personal items).

Guest favourite
The property is illuminated at night, showcasing a spacious terrace with comfortable furniture. Soft lighting highlights the structure's features, while stairs lead to the lower level. A serene atmosphere is created by the surrounding trees and dark sky.
Guesthouse in Mariato
4.96 out of 5 average rating, 82 reviews

Beachfront Nature Rentals, Full floor Studio

1km beautiful sandy beach. STARLINK internet. Peace & Quiet. 4 wheel drive car is not required. Soft rhythmic sound of the waves. Every week; new birds, turtles nesting, dolphins, whales or monkeys. See the stars without light pollution. Ocean is perfect for swimming and sometimes body-boarding. Swim in our pool anytime you like. If you surf, we have walking or driving access to famous surfing beach, Morrillo.

Top guest favourite
A cozy sleeping area features a wooden bed dressed in a floral-patterned quilt and decorative pillows. Soft lighting is provided by bedside lamps, while light filters through a window adorned with sheer curtains, enhancing the calming atmosphere of the room.
Guesthouse in Panamá
4.89 out of 5 average rating, 66 reviews

Private Guest House in Ancón

Enjoy the simplicity of this cozy, quiet and central accommodation. Close to attractions such as the Panama Canal Administration building, Amador Causeway, Albrook Mall, and several restaurants. Personally decorated to provide comfort... large windows in the bedroom provide natural lighting and a view of the garden and green area through the windows; it still maintains the desired privacy and tranquility.

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